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Over the next four years, Gordon received his medical training at the University of Chicago and graduated with honors in In he completed a fellowship in medicine Gastroenterology at Washington University School of Medicine.
In the following years, Gordon rose quickly through the academic ranks at Washington University: Asst. Inhe became head of the Dept.
Gordon's early career focused on the development of cell lineages within the gastrointestinal tract. His laboratory initially combined the use of transgenic mouse models and biochemical approaches to elucidate the mechanisms of gut epithelial development along the duodenal-colonic and crypt-villus axes.
Early studies also provided important insight into biochemical properties of lipid handling and transport in the digestive system. Gordon and colleagues later súlycsökkentő tanulmányok st louis-ban laser capture microdissectionand functional genomics to characterize specified cell populations within the gastrointestinal tract, including multipotent stem cells.
Gordon played a pivotal role in the study of protein N- myristoylationa co-translational modification by which a myristoyl group is covalently attached to an N-terminal glycine residue of a nascent polypeptide.
Gordon and his colleagues were instrumental in characterizing the mechanism by which N-myristoyltransferase the enzyme that catalyzes the myristoylation reaction selects its substrates súlycsökkentő tanulmányok st louis-ban its catalytic mechanism. One of these responses, the induction of intestinal cell surface fucose residues, is elicited by a prominent human intestinal symbiont, Bacteroides thetaiotaomicron, which can harvest and use the host fucose as a carbon and energy source.
Gordon's laboratory has investigated epithelial cell interaction with human-associated pathogens, including uropathogenic Escherichia coliHelicobacter pyloriand Listeria monocytogenes. Present research[ edit ] Dr. Gordon and his laboratory are currently focused on understanding the mutualistic interactions that occur between humans and the trillion commensal microbes that colonize each person's gastrointestinal tract.
To tease apart the complex relationships that exist within this gut micobiota, Dr. Gordon's research program employs germ-free and gnotobiotic mice as model hosts, which may be colonized with defined, simplified microbial communities.
These model intestinal microbiotas are more amenable to well-controlled experimentation. Jeffrey Gordon has become an international pioneer in the study of gut microbial ecology and evolution, using innovative methods to interpret metagenomic and gut microbial genomic sequencing data. In recent studies, Dr. Gordon's lab has established that the gut microbiota plays a role in host fat storage and obesity.